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General (brain) health and performance

1.    Storoschuk K, Gharios RT, Galpin AJ, House BT, Wood TR. Strength and multiple types of physical activity, but not low muscle mass, independently predict cognitive function in NHANES 1999-2002. [Submitted to Lifestyle Medicine]

2.    Storoschuk K, Wood TR, Stubbs BJ. A systematic review and meta-regression of exogenous ketone infusion rates and resulting ketosis – a tool for clinicians and researchers. Frontiers in Physiology [In Press].

3.    Turknett J, Wood TR. Demand Coupling Drives Neurodegeneration: A Model of Age-Related Cognitive Decline and Dementia. Cells. 2022; 11(18):2789. doi: 10.3390/cells11182789. PMID: 36139364

4.    Heath R, Wood TR. Why have the benefits of DHA not been borne out in the treatment and prevention of Alzheimer’s Disease: a narrative review focused on DHA metabolism and adipose tissue. Int J Mol Sci. 2021 Oct 31;22(21):11826. doi: 10.3390/ijms222111826. PMID: 34769257

5.    Scholl J, Mailing L, Wood TR. Reframing nutritional microbiota studies to reflect an inherent metabolic flexibility of the human gut. mBIO 2021 Apr 13;12(2):e00579-21. doi: 10.1128/mBio.00579-21. PMID: 33849977

6.    Potter GDM, Wood T. The Future of Shift Work: Circadian Biology Meets Personalised Medicine and Behavioural Science. Front Nutr. 2020; 7: 116. doi: 10.3389/fnut.2020.00116. PMID: 32850937

7.    Wood T, Nance EA. Disease-directed engineering for physiology-driven treatment interventions. APL Bioengineering. 2019 Dec; 3(4): 040901. doi: 10.1063/1.5117299. PMID: 31673672

8.    Cucuzzella MT, Tondt J, Dockter NE, Saslow L, Wood TR. A low-carbohydrate survey: Evidence for sustainable metabolic syndrome reversal. J Insulin Res. 2017;2(1). doi: 10.4102/jir.v2i1.30

9.    Wood T, Kelly C. Insulin, glucose and beta-hydroxybutyrate responses to a medium-chain triglyceride-based sports supplement: A pilot study. J Insulin Res. 2017;2(1). doi: 10.4102/jir.v2i1.20

10.    Kuhnle GG, Joosen AM, Wood TR, Runswick SA, Griffin JL, Bingham SA. Detection and quantification of sucrose as dietary biomarker using gas chromatography and liquid chromatography with mass spectrometry. Rapid Commun Mass Spectrom. 2008;22(3):279-82. doi: 10.1002/rcm.3355. PMID: 18181249.

General brain health

Preterm birth – clinical studies

1.    Kolnik SE, Marquard R, Brandon O, Puia-Dumitrescu M, Valentine GC, Law JB, Natarajan N, Dighe M, Mourad PD, Wood TR, Mietzsch U. Preterm Infants Variability in Cerebral Near-Infrared Spectroscopy Measurements in the First 72-hours After Birth. Pediatric Research. [In Press]

2.    Perez KM, Puia-Dumitrescu M, Comstock BA, Wood TR, Mayock DE, Heagerty PJ, Juul SE. Patterns of Infections Among Extremely Preterm Infants Enrolled in the Preterm Erythropoietin Neuroprotection (PENUT) Trial. Journal of Clinical Medicine. 2023 Apr 4;12(7):2703. doi: 10.3390/jcm12072703. PMID: 37048786

3.    Brandon O, Perez KM, Kolnik SE, Juul SE, Wood TR, Valentine GC. Increasing Sodium Variability in the First 96-Hours after Birth is Associated with Adverse In-Hospital Outcomes of Preterm Newborns. Curr Dev Nutr. 2023 Jan; 7(1):e100026. doi: 10.1016/j.cdnut.2022.100026

4.    Wood TR, Juul SE, German K, Law JB, Kolnik SE, Puia-Dumitrescu M, Mietzsch U, Gogcu S, Comstock BA, Li S, Mayock DE, Heagerty PJ. Predicting 2-year Neurodevelopmental Outcomes in Extremely Premature Infants Using Graphical Network and Machine Learning Approaches. eClinicalMedicine. 2023 Feb 1; 56:101782. doi: PMID: 36618896

5.    Kolnik SE, Jones K, Upadhyay K, Wood TR, Juul SE, Valentine GC. Increased Adherence to a Neonatal Care Bundle Reduced the Rate of Severe Intraventricular Hemorrhage in Preterm Neonates. Pediatrics. [In Press]

6.    Puia-Dumitrescu M, Wood TR, Comstock BA, Law KB, German K, Perez KM, Gogcu S, Mayock DE, Heagerty PJ, Juul SE. Dexamethasone and (methyl)prednisolone use and 2-year neurodevelopmental outcomes in extremely preterm infants: Results from the PENUT Trial Cohort. JAMA Network Open. 2022 Mar 1;5(3):e221947. doi: 10.1001/jamanetworkopen.2022.1947. PMID: 35275165

7.    Valentine GC, Perez KM, Wood TR, Mayock DE, Comstock BA, Puia-Dumitrescu M, Heagerty PJ, and Juul SE on behalf of the PENUT Trial consortium. Postnatal Maximal Weight Loss, Fluid Administration, and Outcomes in Extremely Preterm Newborns. J Perinatol. 2022 Aug;42(8):1008-1016. doi: 10.1038/s41372-022-01369-7. PMID: 35338252

8.    Heath RJ, Klevebro S, Wood TR. Maternal and neonatal polyunsaturated fatty acid intake and risk of neurodevelopmental impairment in premature infants. Int J Mol Sci. 2022 Jan 9;23(2):700. doi: 10.3390/ijms23020700. PMID: 35054885

9.    Juul SE, Wood TR, Comstock BA, Perez KM, Gogcu S, Puia-Dumitrescu M, Berkelhamer S, Heagerty PJ. Deaths in a modern cohort of extremely preterm infants: Analysis from the PENUT Trial. JAMA Network Open. 2022 Feb 1;5(2):e2146404. doi: 10.1001/jamanetworkopen.2021.46404. PMID: 35129596

10.    Law JB, Comstock BA, Richards TL, Traudt CM, Wood TR, Mayock DE, Heagerty PJ, and Juul SE on behalf of the PENUT Trial consortium. Diffusion Tensor Imaging to Assess the Effect of Early Erythropoietin on Brain Development Among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection (PENUT) Trial. Brain Sci. 2021 Oct 16;11(10):1360. doi: 10.3390/brainsci11101360. PMID: 34679424

11.    Wood TR, Parikh PK, Comstock BA, Law JB, Bammler TK, Mayock DE, Heagerty PJ, Burbacher T, and Juul SE on behalf of the PENUT Trial consortium. Early Biomarkers of Hypoxia and Inflammation and Two-Year Neurodevelopmental Outcomes in the Preterm Erythropoietin Neuroprotection (PENUT) Trial. eBioMedicine. 2021 Oct;72:103605. doi: 10.1016/j.ebiom.2021.103605. PMID: 34619638

12.    Law JB, Wood TR, Gogcu S, Comstock BA, Dighe M, Perez K, Puia-Dumitrescu M, Shaw DW, Wright J, Widness JA, Mayock DE, Heagerty PJ, and Juul SE on behalf of the PENUT Trial consortium. Intracranial Hemorrhage and 2-year Neurodevelopmental Outcomes in Extremely Preterm Infants. J Pediatr. 2021 Nov;238:124-134.e10. doi: 10.1016/j.jpeds.2021.06.071. PMID: 34217769

13.    Puia-Dumitrescu M, Comstock BA, Li S, Heagerty PJ, Perez K, Law JB, Wood TR, Gogcu S,  Mayock DE, and Juul SE on behalf of the PENUT Trial consortium. The use of opioids and benzodiazepines and 2-year neurodevelopmental outcomes in extremely low gestational age infants. JAMA Network Open. 2021 Jul 1;4(7):e2115998. doi: 10.1001/jamanetworkopen.2021.15998. PMID: 34232302

14.    Klevebro S, Juul SE, Wood T. A More Comprehensive Approach to the Neuroprotective Potential of Long-Chain Polyunsaturated Fatty Acids in Preterm Infants Is Needed—Should We Consider Maternal Diet and the n-6:n-3 Fatty Acid Ratio? Front Pediatr. 2019; 7: 533. doi: 10.3389/fped.2019.00533. PMID: 31998669 

Preterm birth clincal

Birth asphyxia and hypoxic-ischaemic encephalopathy – clinical studies

1.    Tetarbe M, Wisnowski JL, Geyer E, Tamrazi B, Wood TR, Mietzsch U, Blüml S, Wu T-W. Cerebral glucose concentration in neonatal encephalopathy during therapeutic hypothermia. J Pediatr [In Press].

2.    Lenahan A, Mietzsch U, Wood TR, Press Callahan K, Weiss EM, Miller DE, German K, Natarajan N, Puia-Dumitrescu M, Esposito V, Kolnik S, Law JB. Characteristics, Genetic Testing, and Diagnoses of Infants with Neonatal Encephalopathy Not Due Hypoxic Ischemic Encephalopathy - A Cohort Study. J Pediatr. 2023 Jun 1:113533. 10.1016/j.jpeds.2023.113533. PMID: 37269901.

3.    Mietzsch U, Wood TR, Wu T-W, Juul SE, Niranjana Natarajan N, Hannah C. Glass HC, Gonzalez FF, Mayock DE, Comstock BA, Heagerty PJ, Wu YW. Glycemic profile during the first 12 hours of life in neonates with HIE is associated with outcome. Pediatrics [In Press].

4.    Mietzsch U, Law JB, Puia-Dumitrescu M, Juul SE, Wood TR. Temperature dysregulation during therapeutic hypothermia predicts long-term outcome in neonates with HIE. J Cereb Blood Flow Metab 2023 Mar 8;271678X231162174. doi: 10.1177/0271678X231162174. PMID: 36883364

5.    Natarajan N, Benedetti G, Perez F, Wood TR, German K, Lockrow J, Puia-Dumitrescu M, Myers E, Mietzsch U. Association between early EEG background and outcomes in infants with mild HIE undergoing therapeutic hypothermia. Pediatr Neurol. 2022 Sep;134:52-58. doi: 10.1016/j.pediatrneurol.2022.06.006. PMID: 35835026

6.    Mietzsch U, Radhakrishnan R, Boyle FA, Juul S, Wood TR. Temperature profile during therapeutic hypothermia as a physiologic biomarker of outcome in neonates with moderate to severe hypoxic-ischemic encephalopathy (HIE). J Physiol. 2020 Jan;598(2):415-424. doi: 10.1113/JP278790. PMID: 31777079

Birth asphyxia clinical

Other neuroscience and neonatology articles

1.    Kukka AJ, Berkelhamer SK, Eilevstjønn J, Wood TR, Basnet O, Ashish KC. Observational study comparing heart rate in crying and non-crying but breathing infants at birth. BMJ Paediatrics Open. 2023 Apr;7(1):e001886. doi: 10.1136/bmjpo-2023-001886. PMID: 37028906

2.    Ashish KC, Kong SYJ, Haaland SH, Eilevstjønn J, Myklebust H, Bastola RC, Wood TR, Niermeyer S, Berkelhamer S. Increased risk of bradycardia in vigorous infants receiving early as compared to delayed cord clamping at birth. J Perinatol. 2022 Dec 31. doi: 10.1038/s41372-022-01593-1. PMID: 36587054

3.    Kolnik SE, Wood TR. Role of Vitamin E in Neonatal Neuroprotection: A Comprehensive Narrative Review. Life. 2022 Jul 20;12(7):1083. doi: 10.3390/life12071083. PMID: 35888171

4.    Liao R, Wood TR, Nance EA. Nanotherapeutic modulation of excitotoxicity and oxidative stress in acute brain injury. Nanobiomedicine. 2020 Nov 4;7. doi: 10.1177/1849543520970819. PMID: 35186151

5.    Wood T, Stubbs BJ, Juul SE. Exogenous ketone bodies as promising neuroprotective agents for developmental brain injury. Dev Neurosci. 2019 May 14;:1-12. doi: 10.1159/000499563. PMID: 31085911

6.    Curtis C, Zhang M, Liao R, Wood T, Nance E. Systems-level thinking for nanoparticle-mediated therapeutic delivery to neurological diseases. WIREs Nanomedicine and Nanobiotechnology. 2017 Mar;9(2). doi: 10.1002/wnan.1422. PMID: 27562224

7.    Wood T, Thoresen M. Physiological Responses to Hypothermia. Seminars in Fetal and Neonatal Medicine. 2015 Apr;20(2):87-96. doi: 10.1016/j.siny.2014.10.005. PMID: 25457082

Neuro & Neo

Neonatal neuroscience – basic science

1.    White OR, Corry KA, Moralejo DH, Law JB, Snyder JM, Mietzsch U, Juul SE, Wood TR. Rectal temperature after hypoxia-ischemia predicts white matter and cortical pathology in the near-term ferret. [Submitted to Pediatric Research]

2.    Gundersen JK, Sabir H, Wood TR, Osredkar D, Falck M, Løberg EM, Walløe L, Menassa DA, Thoresen M. Restraint stress during neonatal hypoxia-ischemia alters brain injury following normothermia and hypothermia. Physiol Rep. 2023 Jan;11(1):e15562. doi: 10.14814/phy2.15562. PMID: 36636750

3.    Kolnik SE, Corry KA, Hildahl K, Filteau J, White OR, Brandon O, Farid L, Shearlock AE, Moralejo DH, Juul SE, Nance EA, Wood TR. Vitamin E Decreases Cytotoxicity and Mitigates Inflammatory and Oxidative Stress Responses in a Ferret Organotypic Brain Slice Model of Neonatal Hypoxia-Ischemia. Dev Neurosci. 2022;44(4-5):233-245. doi: 10.1159/000522485. PMID: 35134797

4.    Gundersen JK, Menassa DA, Wood TR, Walløe L, Thoresen M. The deleterious effect of crossfostering in rat pups on hypoxic-ischemic injury tolerance and hypothermic neuroprotection. Dev Neurosci. 2022;44(4-5):205-213. doi: 10.1159/000521438. PMID: 34915481

5.    Wood TR, Hildahl K, Helmbrecht H, Corry KA, Moralejo DH, Kolnik SE, Prater KE, Juul SE, Nance EA. A ferret brain slice model of oxygen-glucose deprivation captures regional responses to perinatal injury and treatment associated with specific microglial phenotypes. Bioeng Transl Med. 2021 Nov 23;7(2):e10265. doi: 10.1002/btm2.10265. PMID: 35600642

6.    Corry KA, White OR, Shearlock AE, Moralejo DH, Law JB, Snyder JM, Juul SE, Wood TR. Evaluating Neuroprotective Effects of Uridine, Erythropoietin, and Therapeutic Hypothermia in a Ferret Model of Inflammation-Sensitized Hypoxic-Ischemic Encephalopathy. Int J Mol Sci. 2021 Sep 11;22(18):9841. doi: 10.3390/ijms22189841. PMID: 34576001

7.    Joseph A, Nyambura C, Bondurant D, Corry K, Beebout D, Wood TR, Pfaendtner WJ, Nance EA. Formulation and efficacy of catalase-loaded nanoparticles for the treatment of neonatal hypoxic-ischemic encephalopathy. Pharmaceutics. 2021 Jul 23;13(8):1131. doi: 10.3390/pharmaceutics13081131. PMID: 34452092

8.    Wood TR, Vu PT, Comstock BA, Law JB, Mayock DE, Heagerty PJ, Burbacher T, Bammler TK, Juul SE. Cytokine and chemokine responses to injury and treatment in a nonhuman primate model of hypoxic-ischemic encephalopathy treated with hypothermia and erythropoietin. J Cereb Blood Flow Metab. 2021 Aug;41(8):2054-2066. doi: 10.1177/0271678X21991439. PMID: 33554708

9.    Wood TR, Gundersen JK, Falck M, Maes E, Osredkar D, Løberg EM, Sabir H, Walløe L, Thoresen M. Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic-ischaemic brain injury: a single laboratory meta-analysis. Sci Rep. 2020 Jul 2;10(1):10833. doi: 10.1038/s41598-020-67532-2. PMID: 32616806

10.    Liao R, Wood TR, Nance EA. Superoxide dismutase reduces monosodium glutamate-induced injury in an organotypic whole hemisphere brain slice model of excitotoxicity. J Biol Engineering. 2020;Feb 14:3. doi: 10.1186/s13036-020-0226-8

11.    Wood T, Moralejo D, Corry K, Fisher C, Snyder J, Acuna V, Holden-Hunt A, Virk S, White O, Parikh P, Juul SE. A Ferret Model of Inflammation-Sensitized Late Preterm Hypoxic-Ischemic Brain Injury. JoVE. 2019; (153), e60131. doi: 10.3791/60131. PMID: 31814608. 

12.    Wood T, Moralejo D, Corry K, Snyder JM, Traudt C, Curtis C, Nance E, Parikh P, Juul SE. A Ferret Model of Encephalopathy of Prematurity. Dev Neurosci. 2019 May 10;:1-15. doi: 10.1159/000498968. PMID: 31079096

13.    Wood TR, Snyder J, Corry K, Moralejo D, Parikh P, Juul SE. Ontogeny of white matter, toll-like receptor expression, and motor skills in the neonatal ferret. Int J Dev Neurosci. 2018 Nov;70:25-33. doi: 10.1016/j.ijdevneu.2018.05.006. PMID: 29791868

14.    Falck M, Osredkar D, Maes E, Flatebø T, Wood TR, Walløe L, Sabir H, Thoresen M. Hypothermia Is Neuroprotective after Severe Hypoxic-Ischaemic Brain Injury in Neonatal Rats Pre-Exposed to PAM3CSK4. Dev Neurosci. 2018;40(3):189-197. doi: 10.1159/000487798. PMID: 29860252

15.    Joseph A, Wood T, Chen E, Corry K, Snyder J, Juul S, Parikh P, Nance E. Curcumin-Loaded Polymeric Nanoparticles for Neuroprotection in Neonatal Rats with Hypoxic-Ischemic Encephalopathy. Nano Research 2018; 11, 5670–5688. doi: 10.1007/s12274-018-2104-y

16.    Falck M, Osredkar D, Wood TR, Maes E, Flatebø T, Sabir H, Thoresen M. Neonatal Systemic Inflammation Induces Inflammatory Reactions and Brain Apoptosis in a Pathogen-Specific Manner. Neonatology. 2018;113(3):212-220. doi: 10.1159/000481980. PMID: 29275405

17.    Wood T, Hobbs C, Falck M, Brun AC, Løberg EM, Thoresen M. Rectal temperature in the first five hours after hypoxia-ischaemia critically affects neuropathological outcomes in neonatal rats. Pediatric Research. 2018 Feb;83(2):536-544. doi: 10.1038/pr.2017.51. PMID: 28288145

18.    Falck M, Osredkar D, Maes E, Flatebø T, Wood TR, Sabir H, Thoresen M. Hypothermic Neuronal Rescue from Infection-Sensitised Hypoxic-Ischaemic Brain Injury Is Pathogen Dependent. Dev Neurosci. 2017;39(1-4):238-247. doi: 10.1159/000455838. PMID: 28407632

19.    Wood T, Osredkar D, Puchades M, Maes E, Falck M, Flatebø T, Walløe L, Sabir H, Thoresen M. Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia. Sci Rep. 2016 Mar 21;6:23430. doi: 10.1038/srep23430. PMID: 26997257

20.    Wood T, Smit E, Maes E. Osredkar D, Falck M, Elstad M, Thoresen M. Monitoring of cerebral blood flow during hypoxia-ischaemia and resuscitation in the neonatal rat using laser speckle imaging. Physiol Rep. 2016 Apr;4(7). pii: e12749.

21.    Sabir H, Wood T, Gill H, Dingley J, Liu X, Thoresen M. Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs. J Neuro Sci. 2016 Apr 15;363:140-4. doi: 10.1016/j.jns.2016.02.05. PMID: 27000239

22.    Sabir H, Osredkar D, Maes E, Wood T, Thoresen M. Xenon combined with therapeutic hypothermia is not neuroprotective after severe hypoxia-ischemia in neonatal rats. PLoS One. 2016 Jun 2;11(6):e0156759. doi: 10.1371/journal.pone.0156759. PMID: 27253085

23.    Smit E, Liu X, Jary S, Gill H, Wood T, Thoresen M. The effect of resuscitation in 100% oxygen on brain injury in a newborn rat model of severe hypoxic-ischaemic encephalopathy. Resuscitation. 2015 Nov;96:214-9. doi: 10.1016/j.resuscitation.2015.07.050. PMID: 26300234

24.    Osredkar D, Sabir H, Falck M, Wood T, Maes E, Flatebø T, Puchades M, Thoresen M. Hypothermia does not reverse cellular responses caused by lipopolysaccharide in neonatal hypoxic-ischemic brain injury. Dev Neurosci. 2015;37(4-5):390-.7. doi: 10.1159/000430860. PMID: 26087775

25.    Thoresen M, Hobbs CE, Wood T, Chakkarapani E, Dingley J. Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia. J Cereb Blood Flow Metab. 2009 Apr;29(4):707-14. doi: 10.1038/jcbfm.2008.163. PMID: 19142190.

Neonatal neuro
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